Synthesis and potential antineoplastic activity of dehydroabietylamine imidazole derivatives
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چکیده
منابع مشابه
Design and Synthesis of New Imidazole Derivatives of Captopril
A new series of alkylthio imidazole analogues of captopril, an ACE inhibitor used in the treatment of hypertension, was designed and synthesized in order to obtain agents more active than captopril with less side effects. All the compounds thus prepared were purified and characterized by IR, NMR and Mass analytical instruments.
متن کاملDesign and Synthesis of New Imidazole Derivatives of Captopril
A new series of alkylthio imidazole analogues of captopril, an ACE inhibitor used in the treatment of hypertension, was designed and synthesized in order to obtain agents more active than captopril with less side effects. All the compounds thus prepared were purified and characterized by IR, NMR and Mass analytical instruments.
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Benzimidazole, which is a heterocyclic nucleus, plays an important role in various medicines. A number of therapeutic agents such as H1 antihistaminic agent clemizole, a potent opioid analgesic etonitazene, nonnucleoside antiviral compound enviroxime, for promotion of excretion of uric acid irtemazole, non sedating antihistaminic agent astemizole, anti ulcer drugs omeprazole and pentoprazole, a...
متن کاملSynthesis and Insecticide Activity of Octahydroquinazolinone derivatives
A simple method for the synthesis of octahydroquinazolinone derivatives in the presence of BF3.SiO2 and Insecticide activity of these compounds against spodoptera litura was investigated to be comparable to commercial pyrethroid insecticides, Cypermethrin and Cyhalothrin. The structure of the isolated compounds was characterized by 1HNMR and FT-IR spectroscopy.The proposed method had some ad...
متن کاملFacile synthesis of optically active imidazole derivatives.
Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding alpha-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imid...
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ژورنال
عنوان ژورنال: MedChemComm
سال: 2018
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c8md00487k